Using Retinal OCT Angiography to Study Microvascular Problems and Predict Outcomes in Patients with MINOCA Compared to STEMI and Healthy Individuals

What this Trial Is About

Researchers are studying microvascular dysfunction in patients with Myocardial Infarction with Non-Obstructive Coronary Arteries MINOCA by using Optical Coherence Tomography Angiography OCTA. The study also includes healthy individuals and patients with Acute Coronary Syndrome ACS to compare retinal microvascular parameters across these groups. The goal is to better understand differences in microvascular function and the variability within specific MINOCA subgroups such as Takotsubo, vasospastic angina, microvascular angina, and plaque erosion cases. This observational study involves three groups MINOCA patients confirmed by coronary angiography, ACS patients with significant coronary artery stenosis matched to MINOCA patients, and age- and gender-matched healthy controls without cardiovascular disease. Participants will undergo OCTA and other imaging procedures to assess their retinal microvascular function. The study will observe these groups over 24 months to evaluate OCTA changes and their correlation with clinical and imaging biomarkers. Participants will provide written informed consent and attend follow-up visits for imaging and assessments. Researchers will monitor changes in retinal microvascular function using OCTA and review clinical and imaging data to understand microvascular dysfunction in MINOCA and comparison groups. The study excludes those with significant eye diseases, severe systemic illnesses, myocarditis, or pregnancy, ensuring participants can comply with all procedures during the observation period.

Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients