Actively Recruiting
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
Led by University of Pisa · Updated on 2025-07-08
90
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying microvascular dysfunction in patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) by using Optical Coherence Tomography Angiography (OCTA). The study also includes healthy individuals and patients with Acute Coronary Syndrome (ACS) to compare retinal microvascular parameters across these groups. The goal is to better understand differences in microvascular function and the variability within specific MINOCA subgroups such as Takotsubo, vasospastic angina, microvascular angina, and plaque erosion cases. This observational study involves three groups: MINOCA patients confirmed by coronary angiography, ACS patients with significant coronary artery stenosis matched to MINOCA patients, and age- and gender-matched healthy controls without cardiovascular disease. Participants will undergo OCTA and other imaging procedures to assess their retinal microvascular function. The study will observe these groups over 24 months to evaluate OCTA changes and their correlation with clinical and imaging biomarkers. Participants will provide written informed consent and attend follow-up visits for imaging and assessments. Researchers will monitor changes in retinal microvascular function using OCTA and review clinical and imaging data to understand microvascular dysfunction in MINOCA and comparison groups. The study excludes those with significant eye diseases, severe systemic illnesses, myocarditis, or pregnancy, ensuring participants can comply with all procedures during the observation period.
CONDITIONS
Brief Title
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged over 18 years
- Diagnosis of MINOCA confirmed by coronary angiography for the MINOCA group
- Patients with Acute Coronary Syndrome with significant coronary artery stenosis matched to MINOCA patients for gender, age, LVEF at admission, and chronic kidney disease stage
- Healthy individuals matched for age and gender with no history of cardiovascular disease
- Written informed consent obtained
- Ability to undergo OCTA and required imaging procedures
You will not qualify if you...
- Significant ocular diseases such as glaucoma, diabetic retinopathy, or macular degeneration that affect OCTA imaging
- Severe systemic diseases including advanced renal failure, active cancer, or severe liver disease
- For MINOCA group: coronary artery stenosis greater than 50% or functionally significant stenosis (FFR less than 0.8), or myocarditis detected by cardiac MRI
- Pregnant or breastfeeding women
- Inability or unwillingness to comply with study procedures including follow-up visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Initial assessment period
Participants undergo retinal OCTA imaging and other required imaging procedures to evaluate microvascular function.
1 visit (in-person)
Duration - 24 months
Participants are monitored over time to observe changes in retinal OCTA and correlate with clinical and imaging biomarkers.
Periodic visits during the 24 months
Trial Site Locations
Total: 1 location
1
University of Pisa, Cisanello Hospital
Pisa, Pisa, Italy, 56124
Actively Recruiting
Research Team
M
Mattia Alberti, Dr
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here