Actively Recruiting
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
Led by University of Pisa · Updated on 2025-07-08
90
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS patients. The study will compare the retinal microvascular parameters across these groups to determine differences in microvascular function in MINOCA patients. Additionally, in the MINOCA subgroup, the study will further evaluate the differences in microvascular dysfunction within specific subsets of patients (e.g., Takotsubo, vasospastic angina, microvascular angina, patients with evidence of plaque erosion) to understand the variability and potential mechanisms underlying each subgroup of MINOCA.
CONDITIONS
Official Title
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged > 18
- Diagnosis of MINOCA confirmed by coronary angiography for MINOCA group
- Patients with Acute Coronary Syndrome with significant coronary artery stenosis matched to MINOCA group by gender, age, LVEF, and kidney disease stage for ACS group
- Age and gender-matched healthy individuals with no cardiovascular disease history for healthy controls
- Written informed consent obtained
- Ability to undergo OCTA and required imaging procedures
You will not qualify if you...
- Significant ocular diseases such as glaucoma, diabetic retinopathy, or macular degeneration that affect OCTA imaging
- Severe systemic diseases like advanced renal failure, active cancer, or severe liver disease
- For MINOCA group: coronary artery stenosis > 50% or functionally significant stenosis (FFR < 0.8), or myocarditis detected by cardiac magnetic resonance
- Pregnant or breastfeeding women
- Inability or unwillingness to comply with study procedures including follow-up visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pisa, Cisanello Hospital
Pisa, Pisa, Italy, 56124
Actively Recruiting
Research Team
M
Mattia Alberti, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here