Actively Recruiting
Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study
Led by Medical University of Vienna · Updated on 2025-05-16
35
Participants Needed
1
Research Sites
391 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems. This can be used as a biomarker for the function of the photoreceptors. Due to the high technical demands on the system, however, the technique is currently not available for clinical purposes. In this pilot study a protocol to measure changes in retinal photoreceptor layer thickness before and after light stimulation shall be developed based on a commercial OCT system and newly developed algorithms. Other variables, such as circadian processes shall be investigated as well. After measurements in healthy volunteers, the protocol is planned to be applied in patients with primary open angle glaucoma (POAG) and age-related macular degeneration (AMD) to test for feasibility of the method in these patient groups.
CONDITIONS
Official Title
Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women aged over 18 years
- Signed informed consent form
- Ametropia below 3 diopters
- Ability and willingness to follow instructions
- Normal eye exam findings for healthy volunteers
- Diagnosed primary open-angle glaucoma with MD 3 dB for POAG patients
- Diagnosed dry age-related macular degeneration, stage II or III for AMD patients
You will not qualify if you...
- Any abnormalities preventing reliable measurements
- Eye inflammation or diseases interfering with study goals
- Use of photosensitizing medications in the past 3 months
- Conditions causing photosensitivity such as lupus, porphyria, vitiligo, xeroderma pigmentosum, or albinism
- Any form of epilepsy
- Eye surgery within the past 3 months
- Pregnancy, planned pregnancy, or breastfeeding
- Any severe acute or chronic medical or surgical disorder or disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Medical University of Vienna, Department of Clinical Pharmacology
Vienna, State of Vienna, Austria, 1090
Actively Recruiting
Research Team
D
Doreen Schmidl, MD,PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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