Actively Recruiting
Retinal Vessel Leakage in Cerebral Small Vessel Disease
Led by University of Edinburgh · Updated on 2026-03-04
40
Participants Needed
1
Research Sites
213 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: * Does retinal vessel leakage occur in cerebral small vessel disease? * If it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally? Participants will be tested using fluorescein angiography. This involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels. Participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. Our new retinal images will complement the information from these previous tests.
CONDITIONS
Official Title
Retinal Vessel Leakage in Cerebral Small Vessel Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Membership in the Mild Stroke Study 3 cohort
- Contrast enhanced MRI within 12 months
- Clear optical media in both eyes, as assessed by study investigator
- Best corrected visual acuity (near vision) ≥N36
You will not qualify if you...
- Any condition known to cause retinal leakage worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, or malignant hypertension
- Previous treatment for retinal leakage such as retinal laser or intravitreal anti-VEGF
- Recent eye surgery
- Shallow anterior chambers as assessed by torch test
- Pregnancy or renal failure
- Severe dementia
- Known allergy to fluorescein
- History of allergies such as food or drug induced urticaria or bronchial asthma
- Any other severe or acute medical or psychiatric conditions
- Inability to give informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
NHS Lothian
Edinburgh, United Kingdom
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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