Actively Recruiting
Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery
Led by Duke University · Updated on 2025-08-15
30
Participants Needed
2
Research Sites
97 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to compare brain function after surgical circulatory arrest using either antegrade perfusion or retrograde perfusion.
CONDITIONS
Official Title
Retrograde Versus Antegrade Perfusion in Low-Moderate Hypothermia for Aortic Arch Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be older than 18 years
- Scheduled for elective proximal aortic reconstructive surgery with proximal hemi-arch replacement via median sternotomy
You will not qualify if you...
- Younger than 18 years of age
- History of symptomatic cerebrovascular disease such as prior stroke with lasting deficits
- Current alcoholism defined as more than 2 drinks per day
- Current psychiatric illness requiring medication
- Current drug abuse including any illicit drug use in the past 3 months
- Liver problems with liver function tests over 1.5 times the normal upper limit
- Severe lung problems requiring home oxygen therapy
- Kidney failure with serum creatinine over 2.0 mg/dL
- Claustrophobia
- Unable to read and complete cognitive testing
- Pregnant women
- Patients scoring less than 19 on the Montreal Cognitive Assessment or 27 or higher on the baseline depression scale (CES-D)
- Patients with unsafe implants for 3 Tesla MRI
- Patients who have received chemotherapy in the last 12 months or brain radiation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Duke Univeristy
Durham, North Carolina, United States, 27710
Not Yet Recruiting
2
Duke Univeristy
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
K
Kelly Rodden, BSN
CONTACT
B
Bonita Hilliard, RPM
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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