Actively Recruiting
A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center
Led by Methodist Health System · Updated on 2026-05-01
500
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Hepatorenal syndrome (HRS) is a common cause of acute kidney injury (AKI) in patients with liver disease \[1\]. Increased activity and presence of vasodilators such as nitric oxide in cirrhotic patients leads to vasodilation, especially in the splanchnic circulation, resulting in hemodynamic changes that precipitate renal injury \[1\]. Patients may present with elevated serum creatinine (Cr), benign urine sediment, and low urine sodium \[1\].
CONDITIONS
Official Title
A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years hospitalized between April 1, 2019 and April 1, 2023
- Diagnosis of HRS-AKI either at admission or during hospital stay
- Presence of cirrhosis, acute liver failure, or acute-on-chronic liver failure
- Increase in serum creatinine of at least 0.3 mg/dL within 48 hours or 50% increase from baseline, or low urine output for 6 hours
- No response for at least 2 days after stopping diuretics and receiving albumin treatment
- No shock present
- No current or recent use of nephrotoxic drugs
- No parenchymal kidney disease
- Evidence of kidney blood vessel constriction based on specific urine sodium measurement
You will not qualify if you...
- Patients younger than 18 years
- Patients hospitalized in the same period without a diagnosis of HRS-AKI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Liver Institute of Methodist Dallas Medical Center
Dallas, Texas, United States, 75203
Actively Recruiting
Research Team
C
Colette Ngo Ndjom, MS
CONTACT
L
Loretta W Bedell, MPH
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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