Actively Recruiting
A Retrospective Study of EGFR-TKIs,Gefitinib, Erlotinib and Osimertinib in NSCLC Patients Treatment
Led by Sun Yat-sen University · Updated on 2023-04-12
1000
Participants Needed
1
Research Sites
743 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For patients of advanced NSCLC (non small cell lung cancer) , Individualized cancer therapy has been widely accepted since the success of crizotinib administration based on EML4-ALK fusion gene detection and gefitinib and erlotinib administration based on EGFR-TKIs sensitive mutations.From clinical points of view ,individual differences often occur between different patients, leading diverse effect in ADR and drug effect.Meanwhile ,the drug effect and adverse drug reaction was significantly influenced by the pharmacokinetic factors and pharmacodynamic factors.In this research ,we try to establish a more sensitive method to detect sensitive mutations in plasma and discover the correlation between somatic and germline mutations , trough concentration and EGFR-TKI drug effect, the association between ADME-associated SNP ,trough concentration and EGFR-TKI adverse effect .Furthermore, in vivo and in vitro research is also crucial for rational explanation for these clinical phenomenon.
CONDITIONS
Official Title
A Retrospective Study of EGFR-TKIs,Gefitinib, Erlotinib and Osimertinib in NSCLC Patients Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Histologically and cytologically confirmed non-small cell lung cancer (NSCLC)
- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less
- Adequate blood, kidney, and liver function
You will not qualify if you...
- Uncontrolled systemic diseases
- Clinically active interstitial lung diseases
- Receiving other chemotherapy treatments at the time of inclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
Cancer Center, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
S
shaoxing guan, PHD
CONTACT
M
Min Huang, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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