Actively Recruiting
Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)
Led by VA Office of Research and Development · Updated on 2026-03-13
160
Participants Needed
2
Research Sites
251 weeks
Total Duration
On this page
Sponsors
V
VA Office of Research and Development
Lead Sponsor
V
Vanderbilt University Medical Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI). ICU-LTCI causes considerable problems with personal relationships, return to work, and everyday tasks, such as managing medicines and money. No treatment for these patients is currently available. Technology using computerized cognitive rehabilitation could improve ICU-LTCI by harnessing the healing potential of the brain (i.e., neuroplasticity). This intervention is scalable, portable, and economical. The investigators will evaluate the effectiveness of computerized cognitive rehabilitation in a randomized controlled trial of 160 ICU survivors. The investigators hypothesize that this intervention could improve cognition. This research has high potential to influence rehabilitation strategies for Veteran and civilian ICU survivors.
CONDITIONS
Official Title
Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with a recent medical or surgical ICU stay requiring treatment for respiratory failure and/or shock
- No longer requiring ICU-level care
You will not qualify if you...
- History of severe cognitive impairment before ICU (IQCODE≥3.8 or documented in medical record)
- Unwilling to participate in the intervention
- Under consideration for hospice care
- Primary residence over 100 miles from enrolling site without willingness to return for follow-up
- Homeless without a secondary contact available
- Severe substance abuse or neuropsychiatric disorder preventing independent living
- Active suicidal thoughts
- Any past or present behavior posing safety risks for follow-up
- Blind, deaf, or unable to understand or communicate in English
- Required ICU-level care for less than 24 hours
- Unable to complete computer-based training
- Enrolled in another study
- Currently incarcerated
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States, 37212-2637
Actively Recruiting
2
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212
Actively Recruiting
Research Team
M
Mayur B Patel, MD MPH
CONTACT
E
E. Wesley Ely, MD MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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