Neuroimaging standards for research into small vessel disease-advances since 2013.
Marco Duering, Geert Jan Biessels, Amy Brodtmann...
https://pubmed.ncbi.nlm.nih.gov/37236211Actively Recruiting
Age: 40Years - 80Years
All Genders
ID06031610
Revascularization Effect on CSVD Burden in Carotid Artery Stenosis
Led by Zhejiang Provincial People's Hospital · Updated on 2025-02-12
1000
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
RECAS is a prospective cohort of 1,000 patients with carotid artery stenosis (CAS) and undergoing revascularization therapy or standard medication treatment alone. The goal of this study is to validate whether CAS revascularization when compared to standard medication treatment alone, can effectively reduce the progression of Cerebral small vessel disease (CSVD) burden, as well as improve the severity of retinal pathologies and cognitive impairment. Therefore, Patients aged ≥ 40 years have more than 50% stenosis in unilateral carotid artery and sign informed consent will be recruited. In this study, patients will be asked to undergo Computed Tomography Angiography (CTA)/ Digital Subtraction Angiography (DSA), Computed Tomography Perfusion (CTP),multimodal Magnetic Resonance Imaging (MRI), Optical Coherence Tomography Angiography (OCTA) and neuropsychological testing. Estimated follow-up can be up to 10 years.
CONDITIONS
Brief Title
Revascularization Effect on CSVD Burden in Carotid Artery Stenosis
Who Can Participate
Age: 40Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Patients aged ≥ 40 years.
- ≥ 50% stenosis in unilateral carotid artery.
- Sign informed consent.
You will not qualify if you...
- Previous history of major head trauma and any intracranial surgery
- Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage, and other space occupying lesions
- Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement.
- Severe loss of vision, hearing, or communicative ability.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Trial Site Locations
Total: 1 location
1
Zhejiang Provincial People's Hospital
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
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Research Team
S
Sheng Zhang, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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