Actively Recruiting
REVerse Intestinal Metaplasia in the Stomach (REVISE)
Led by Katherine Garman · Updated on 2026-02-12
32
Participants Needed
1
Research Sites
41 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to test the use of Pyrvinium vs placebo as a treatment for gastric intestinal metaplasia with features associated with increased risk of cancer. Response will be determined by assessing the extent and quality of the gastric intestinal metaplasia before and after treatment. A secondary aim will be to generate gastric organoids from patient-derived samples to test the effects of pyrvinium in vitro in patient-derived samples, and also to identify new drugs that may help reverse gastric intestinal metaplasia.
CONDITIONS
Official Title
REVerse Intestinal Metaplasia in the Stomach (REVISE)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults over age 18, including men, women, and non-binary individuals, with known gastric intestinal metaplasia (GIM) having at least one high-risk feature such as extensive vs limited GIM, incomplete or mixed-type GIM, or family history of stomach cancer
- Ability to provide informed consent
- Evidence of prior but not active Helicobacter pylori infection
You will not qualify if you...
- Diagnosis of active gastric cancer
- High risk of bleeding complications due to use of anticoagulants or underlying medical conditions
- Pregnancy, due to risks associated with anesthesia in non-emergency endoscopy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Duke Health
Durham, North Carolina, United States, 27710
Actively Recruiting
Research Team
N
Nicole Pavlus
CONTACT
L
Laura Hayes, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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