Actively Recruiting
Reverse Trigger Phenotypification and Response to Ventilatory Adjustments
Led by Hospital Civil de Guadalajara · Updated on 2025-03-18
130
Participants Needed
1
Research Sites
115 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS). The main questions it aims to answer are: * Real incidence of RT based on continuous monitoring * The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)/sedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation/neuromuscular blockers by medical indication, or death. In order to allow detection of possible RT in patients with ongoing sedation/NMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.
CONDITIONS
Official Title
Reverse Trigger Phenotypification and Response to Ventilatory Adjustments
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of ARDS according to the Berlin criteria and New Global Definition 2023
- Mechanical ventilation
You will not qualify if you...
- Younger than 18 years
- Having a tracheostomy
- Pneumothorax
- Tube thoracostomy with air leaks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital Civil Fray Antonio Alcalde
Guadalajara, Mexico, 44280
Actively Recruiting
Research Team
M
Miguel Ibarra-Estrada, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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