Actively Recruiting

Age: 18Years - 90Years
All Genders
NCT06148467

Reverse Trigger Phenotypification and Response to Ventilatory Adjustments

Led by Hospital Civil de Guadalajara · Updated on 2025-03-18

130

Participants Needed

1

Research Sites

115 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS). The main questions it aims to answer are: * Real incidence of RT based on continuous monitoring * The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)/sedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation/neuromuscular blockers by medical indication, or death. In order to allow detection of possible RT in patients with ongoing sedation/NMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.

CONDITIONS

Official Title

Reverse Trigger Phenotypification and Response to Ventilatory Adjustments

Who Can Participate

Age: 18Years - 90Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnosis of ARDS according to the Berlin criteria and New Global Definition 2023
  • Mechanical ventilation
Not Eligible

You will not qualify if you...

  • Younger than 18 years
  • Having a tracheostomy
  • Pneumothorax
  • Tube thoracostomy with air leaks

AI-Screening

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Trial Site Locations

Total: 1 location

1

Hospital Civil Fray Antonio Alcalde

Guadalajara, Mexico, 44280

Actively Recruiting

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Research Team

M

Miguel Ibarra-Estrada, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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