What this Trial Is About

Researchers are studying how high blood sugar levels affect the brain in people with poorly controlled Type 2 Diabetes Mellitus (T2DM) and whether improving blood sugar control can reverse these changes. The study focuses on understanding if abnormal brain glucose transport in uncontrolled diabetes can improve with better glucose management and which factors like diabetes duration and blood sugar control impact these changes. Participants will undergo a screening visit and use a continuous glucose monitor (CGM) starting two weeks before the first brain scan at week 0. They will attend nutrition visits every two weeks for exercise and dietary counseling and meet with an endocrinologist in person or by phone every two weeks to review and intensify diabetes treatment as needed. A second brain scan will be performed at week 12 to assess changes. During the 12-week study, participants will have their brain glucose levels measured using magnetic resonance spectroscopy (MRS) at the start and end of the study. Researchers will monitor blood glucose levels through the CGM, aiming for specific glucose targets before meals and at bedtime. Regular contact via phone, email, or clinic visits will support maintaining glucose control. Safety and treatment effects will be closely followed throughout the study period.

Reversibility of Brain Glucose Transport in Type 2 Diabetes Mellitus (T2DM)