Safety and Effectiveness of a New Ultrasound-Guided Radiofrequency Ablation Approach for Genicular Nerves in Knee Osteoarthritis

What this Trial Is About

Researchers are evaluating a new ultrasound-guided radiofrequency ablation RFA method for treating long-term knee pain caused by joint damage, specifically moderate to severe osteoarthritis. This study focuses on a novel targeting protocol for the genicular nerves around the knee, based on recent anatomical research to improve accuracy and consistency in nerve localization. The aim is to see if this new approach can safely reduce pain and improve movement for people who have not found relief from medicines, physical therapy, or joint injections. Participants will receive a single-session ultrasound-guided thermal RFA treatment targeting three specific genicular nerve branches around the knee. The procedure uses local anesthesia and involves inserting radiofrequency needles under ultrasound guidance. Sensory and motor stimulations confirm correct needle placement before applying heat at 85C for 90 seconds at each site. This approach avoids fluoroscopy and follows updated anatomical landmarks to enhance precision. The treatment session is one-time, with follow-up scheduled for two years. During the study, participants will complete questionnaires about their knee pain and function before treatment and multiple times afterward. Researchers will monitor changes in pain intensity, physical function, and any side effects, including a phone call one week after the procedure to check for any adverse events. The primary outcome is pain change at three months, with additional assessments extending up to two years. The study is free to join, voluntary, and all personal information is kept confidential.

Revised Targets for Knee Radiofrequency Ablation