Actively Recruiting
Routine Evaluation of People Living With Cancer - Surgery
Led by University of Edinburgh · Updated on 2025-12-02
200
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Edinburgh
Lead Sponsor
N
NHS Lothian
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying people with cancer who may experience muscle wasting, weight loss, and tiredness, a condition called cachexia. Cachexia can affect quality and length of life and may start early even in patients planned for surgery to remove cancer. This study aims to collect detailed information about body composition, physical activity, quality of life, and the body's immune response in patients at risk of cachexia, including those undergoing surgery for cancers of the oesophagus, stomach, pancreas, colon, or rectum, as well as a small group of patients without cancer having surgery for benign conditions. Participants will have their height and weight measured, complete questionnaires on quality of life, and undergo assessments of physical function and activity levels. Blood samples will be taken to analyze inflammation markers, and body composition will be measured by different methods. Some participants will also have MRI scans of their abdomen and thighs. During surgery, small biopsies of muscle, fat, tumor, and urine will be collected for analysis. Cancer patients will be asked to return for three follow-up visits over the year after surgery to repeat these assessments. Throughout the study, researchers will track changes in weight, muscle and fat composition by CT scans, inflammation, physical activity, muscle strength and function, nutritional risk, and quality of life at several time points including before and after surgery and any cancer treatments. Muscle biopsies will be repeated in some participants to observe tissue-level changes. The study will also evaluate how MRI scans correlate with tissue changes and physical function before surgery. This comprehensive approach aims to better understand cachexia's impact on surgical cancer patients over time.
CONDITIONS
Brief Title
REVOLUTION Surgery (REVOLUTION Surgery)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with cancer confirmed by clinical, histological, cytological, or radiological evidence planned for surgical removal of oesophagus, stomach, pancreas, colon, or rectum malignancy
- Aged 18 years and over
- Able to give written informed consent
- Patients planned for open abdominal surgery for a non-inflammatory, benign condition (e.g., donor nephrectomy)
- Aged 18 years and over
- Able to give written informed consent
You will not qualify if you...
- Any medical or psychiatric condition that increases risk of complications for participant or investigator
- Presence of inflammatory or muscle wasting conditions other than cancer, such as rheumatoid arthritis or inflammatory bowel disease
- Pregnancy
- Claustrophobia
- Implanted medical devices like cardiac pacemaker, metallic foreign bodies, or aneurysm clip preventing MRI
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgical day and immediate recovery period
Participants undergo surgical resection of their cancer or benign condition. Tissue samples and imaging are collected during this period.
1 visit (in-person)
Duration - Up to 12 months post-surgery
Participants are followed for up to 12 months to monitor changes in weight, body composition, inflammation, physical function, and quality of life. Repeat imaging, biopsies, and physical assessments are performed at scheduled intervals.
Visits at 6 weeks, 6 months, and 12 months post-surgery
Trial Site Locations
Total: 1 location
1
University of Edinburgh
Edinburgh, United Kingdom
Actively Recruiting
Research Team
R
Richard JE Skipworth, MD FRCS
L
Leo R Brown, MBChB MRCS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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