Actively Recruiting
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Led by San Francisco Veterans Affairs Medical Center · Updated on 2024-08-02
150
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception, including individual variation in symptoms, severity, and treatment response. This heterogeneity complicates understanding of depression and thwarts progress toward disease classification and treatment planning. Discovery of depression-specific biomarkers that account for neurobiological variation that presumably underlies distinct clinical manifestations is critical to this larger effort.
CONDITIONS
Official Title
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 70 years
- Diagnosis of major depressive disorder for MDD group or no diagnosis for healthy comparison group
- Negative metal screening for MRI safety
- Normal or corrected-to-normal vision
You will not qualify if you...
- Past or present neurological problems including seizures or head trauma with symptoms
- Loss of consciousness longer than 30 minutes or with neurological symptoms
- Major medical conditions such as seizure disorders, endocrine disorders, or significant heart problems
- Substance dependence within the past year or positive urine toxicology on neuroimaging days
- Known claustrophobia
- Current pregnancy
- IQ estimate below 70
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
San Francisco Healthcare System
San Francisco, California, United States, 94121
Actively Recruiting
Research Team
J
Jason Hemmerle, MBA
CONTACT
K
Kaitlyn Dal Bon, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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