The natural history of benign thyroid nodules.
Cosimo Durante, Giuseppe Costante, Giuseppe Lucisano...
https://pubmed.ncbi.nlm.nih.gov/25734734Actively Recruiting
Age: 18Years +
All Genders
ID05189821
RFA Treatment for Papillary Thyroid Microcarcinoma Cohort
Led by Columbia University · Updated on 2026-05-29
50
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate the safety and effectiveness of Radiofrequency Ablation (RFA) for treating Papillary Thyroid Microcarcinoma (PTMC), a small, low-risk type of thyroid cancer. The study is observational and collects data from patients who have already agreed to undergo RFA based on their doctor's recommendation. The goal is to explore less invasive treatment options compared to traditional thyroid surgery, which carries risks like nerve injury, hormone issues, and scarring. The RFA procedure uses ultrasound guidance to insert an electrode through the skin into the tumor. High-frequency electrical currents generate heat to treat the lesion, offering a minimally invasive alternative to surgery. This study collects information generated before and after RFA treatment to assess outcomes over time. Participants provide access to their medical data related to the RFA treatment and undergo regular sonographic evaluations. Researchers monitor for complete disappearance of the tumor on ultrasound at 12 months and track any complications. The study follows patients over at least a year to understand the treatment's safety and long-term effects.
CONDITIONS
Brief Title
RFA Treatment for Papillary Thyroid Microcarcinoma
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult patients (18 years or older)
- Biopsy proven papillary thyroid microcarcinoma (1.5 cm or larger in greatest diameter)
- Patients who refuse surgery or are not good surgical candidates
You will not qualify if you...
- Cardiac arrhythmia
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Implementation
Duration - Single procedure
Participants undergo ultrasound-guided radiofrequency ablation as a treatment procedure for papillary thyroid microcarcinoma.
1 procedure visit (in-person)
Long-term Monitoring
Duration - 12 months
Participants are monitored with follow-up assessments to evaluate treatment outcomes and complications.
Periodic follow-up visits over 12 months
Trial Site Locations
Total: 1 location
1
Columbia University
New York, New York, United States, 10032
Actively Recruiting
Loading map...
Research Team
J
Jennifer H Kuo, MD MS
V
Vilma Rosario
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Published Research Related To This Trial
Unilateral benign multinodular versus solitary goiter: Long-term contralateral reoperation rates after lobectomy.
Beatriz de Rienzo-Madero, John P Sabra, Elise Gand...
https://pubmed.ncbi.nlm.nih.gov/30415868Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience.
Young-Sun Kim, Hyunchul Rhim, Kyung Tae...
https://pubmed.ncbi.nlm.nih.gov/16646682Radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: consensus statement and recommendations.
Dong Gyu Na, Jeong Hyun Lee, So Lyung Jung...
https://pubmed.ncbi.nlm.nih.gov/224386782017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology.
Ji-Hoon Kim, Jung Hwan Baek, Hyun Kyung Lim...
https://pubmed.ncbi.nlm.nih.gov/29962870AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ASSOCIAZIONE MEDICI ENDOCRINOLOGI MEDICAL GUIDELINES FOR CLINICAL PRACTICE FOR THE DIAGNOSIS AND MANAGEMENT OF THYROID NODULES--2016 UPDATE.
Hossein Gharib, Enrico Papini, Jeffrey R Garber...
https://pubmed.ncbi.nlm.nih.gov/27167915Radiofrequency ablation of benign thyroid nodules: safety and imaging follow-up in 236 patients.
Woo Kyoung Jeong, Jung Hwan Baek, Hyunchul Rhim...
https://pubmed.ncbi.nlm.nih.gov/18286289Benign predominantly solid thyroid nodules: prospective study of efficacy of sonographically guided radiofrequency ablation versus control condition.
Jung Hwan Baek, Yoon Suk Kim, Ducky Lee...
https://pubmed.ncbi.nlm.nih.gov/20308523Cross-cultural validity of the thyroid-specific quality-of-life patient-reported outcome measure, ThyPRO.
Torquil Watt, Giuseppe Barbesino, Jakob Bue Bjorner...
https://pubmed.ncbi.nlm.nih.gov/25194574Monopolar Radiofrequency Ablation of Thyroid Nodules: A Prospective Austrian Single-Center Study.
Harald Dobnig, Karin Amrein
https://pubmed.ncbi.nlm.nih.gov/29490593