Actively Recruiting
rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study
Led by Centrum Clinic IVF Center · Updated on 2026-02-03
300
Participants Needed
2
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to compare two commonly used hormone treatments for women undergoing IVF. All participants will receive a stimulation protocol that includes dydrogesterone, a medication used to safely control natural hormone surges during treatment. The study will observe women who are treated either with recombinant FSH alone or with a combination of recombinant FSH and recombinant LH-both routinely used options in our clinic. Investigators will prospectively monitor how these treatments affect the growth of ovarian follicles, the number of mature eggs collected, the quality of developing embryos, and early pregnancy outcomes. No additional procedures or medications will be required beyond standard IVF care. The goal is to better understand whether adding recombinant LH provides any measurable benefit in dydrogesterone-based PPOS cycles.
CONDITIONS
Official Title
rFSH vs rFSH+rLH in Dydrogesterone-Based Progestin Protocol: A Prospective Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 20 to 43 years
- BMI less than 30 kg/m²
- AMH greater than 1 ng/mL
- Undergoing IVF/ICSI treatment with a dydrogesterone-based PPOS protocol
- Women with regular menstrual cycles or clinically acceptable cycle pattern for stimulation
- Ability to provide informed consent and comply with study procedures
- Presence of at least one ovary and eligibility for controlled ovarian stimulation
You will not qualify if you...
- Cycle cancellation due to lack of viable embryos
- Prior or planned preimplantation genetic testing for aneuploidy (PGT-A) in the same cycle
- Adenomyosis diagnosed by ultrasound or MRI
- Uncorrected uterine anomalies such as bicornuate, unicornuate, or didelphys uterus
- Presence of hydrosalpinx
- Use of oral contraceptives or luteal-phase estradiol within 3 months before stimulation
- Refusal or inability to provide informed consent
- Severe systemic disease or contraindication to ovarian stimulation
- Prior bilateral oophorectomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Centrum Clinic IVF Center
Ankara, Ankara, Turkey (Türkiye), 06800
Actively Recruiting
2
Bahçeci IVF Center
Ankara, Turkey (Türkiye)
Actively Recruiting
Research Team
E
Emre G pabuçcu, Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here