Actively Recruiting
Rheumatoid Arthritis and Osteosarcopenia: Associated Factors
Led by Konya Beyhekim Training and Research Hospital · Updated on 2025-07-10
200
Participants Needed
1
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Our study is a cross-sectional study, and its aim is to compare and analyze the prevalence of sarcopenia and osteoporosis in patients with rheumatoid arthritis (RA) with a control group and to reveal the impact of sarcopenia on osteoporosis, fall risk, and fracture risk. This prospective cross-sectional study will include 100 rheumatoid arthritis patients and 100 healthy controls, matched for age and sex. Patients will be consecutively and meticulously enrolled based on inclusion and exclusion criteria. A detailed medical history and examination will be performed on the patients, and their clinical and sociodemographic characteristics will be recorded. Blood tests for RA (RF, Anti-Cyclic Citrullinated Peptide (anti-CCP), CRP, ESR) and disease activity levels (DAS28) will be recorded. The prevalence of osteosarcopenia will be assessed in both the RA and healthy control groups.These groups will be evaluated using various scales and tests (including power, performance tests) including musculoskeletal ultrasonographic measurements and clinical functional assessment tests. he sarcopenic group will be categorized based on the level of sarcopenia, according to the new ISarcoPRM criteria (non-sarcopenic, dynapenic, sarcopenic, and severe sarcopenic). Osteosarcopenia will be evaluated for both groups, and the collected data will be analyzed with primary and secondary outcomes. The analysis will explore the potential relationships between rheumatoid inflammation, sarcopenia, and osteoporosis.
CONDITIONS
Official Title
Rheumatoid Arthritis and Osteosarcopenia: Associated Factors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with rheumatoid arthritis according to ACR/EULAR 2010 criteria
- Male or female aged 50 years or older
- Able mentally and physically to complete study questionnaires and tests
- Provided voluntary consent by signing the informed consent form
You will not qualify if you...
- Having an acute illness, disability, or cognitive impairment that prevents understanding or performing tests
- Having thyroid or parathyroid disease, uncontrolled diabetes, Cushing's syndrome, or anemia
- History of malignancy
- Severe cardiovascular disease, renal failure, advanced COPD, or decompensated liver disease
- History of gastrointestinal surgery
- Having another autoimmune or inflammatory rheumatic disease such as SLE, ankylosing spondylitis, psoriatic arthritis, vasculitis, or familial Mediterranean fever
- Severe or symptomatic hand osteoarthritis or deformities
- Severe or symptomatic osteoarthritis in the knee, lumbar, hip, or ankle
- Having carpal tunnel syndrome, De Quervain, lateral epicondylitis, cubital tunnel syndrome, or past traumatic hand injury
- Significant neurological diseases like stroke, MS, myopathy, Parkinson's, radiculopathy, polyneuropathy, brachial plexopathy, or nerve root compression
- History of surgical intervention on upper or lower extremities or spine
- Severe kyphosis or scoliosis
- Any other disease causing balance disorders (neurological, orthopedic, metabolic, etc.)
- Major psychiatric disorder based on medical history and records
- Current use of androgens or estrogens
- Having prostheses, being fully dependent, or immobilized
AI-Screening
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Trial Site Locations
Total: 1 location
1
Konya Beyhekim Training and Research Hospital Physical Medicine and Rehabilitation Clinic
Konya, Selçuklu, Turkey (Türkiye), 42000
Actively Recruiting
Research Team
I
ilhan ç KAYA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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