Actively Recruiting
Rheumatology Patient Registry and Biorepository for Comparative Analysis of Rheumatic Diseases
Led by Yale University · Updated on 2026-02-13
5000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
R
Rheumatology Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are creating a biorepository to support clinical, basic science, and translational research on various rheumatic diseases. This registry includes patients diagnosed with conditions such as adult onset Still's disease, ankylosing spondylitis, psoriatic arthritis, systemic lupus erythematosus, rheumatoid arthritis, and other related autoimmune disorders. The goal is to improve understanding of disease development through comparative analyses across these diseases. Participants diagnosed with rheumatic diseases and receiving care at Yale Rheumatology clinics contribute biospecimen samples including blood, saliva, urine, stool, and tissue. Healthy volunteers without rheumatic autoimmune diseases may also participate. The study does not involve treatment interventions but collects samples and clinical data for research purposes. During participation, patients provide biological samples and clinical information which researchers use to correlate outcomes and disease biomarkers over a 10-year period. The study includes long-term follow-up to observe disease patterns and biomarker relationships. Participants may be asked to complete questionnaires and undergo evaluations as part of routine clinical care during their involvement.
CONDITIONS
Brief Title
Rheumatology Patient Registry and Biorepository
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older with a diagnosis of a rheumatic autoimmune disease such as adult onset Still's disease, ankylosing spondylitis, antiphospholipid syndrome, Behcet's disease, dermatomyositis, giant cell arteritis, mixed connective tissue disease, polymyalgia rheumatica, polymyositis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, sarcoidosis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus, undifferentiated connective tissue disease, or vasculitis
- Receiving clinical care at Yale Rheumatology clinics
- Healthy volunteers aged 18 years or older with no chronic skin conditions
- Healthy volunteers with no diagnosis of rheumatic autoimmune disease
- Healthy volunteers with normal body mass index (BMI)
You will not qualify if you...
- Unable to provide informed consent
- Women currently pregnant must wait to donate a skin biopsy until after delivery
- Patients allergic to lidocaine or epinephrine or with a history of impaired wound healing cannot donate a skin biopsy
- Healthy volunteers currently pregnant or nursing unless the study goal includes them
- Healthy volunteers with allergies to lidocaine or epinephrine
- Healthy volunteers with a history of impaired wound healing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 10 years
Participants provide biospecimen samples such as blood, saliva, urine, stool, and tissue for analysis.
Occasional visits to provide biospecimens
Duration - Up to 10 years
Participants are monitored over time to correlate outcomes and biomarkers of rheumatic diseases.
Trial Site Locations
Total: 1 location
1
Yale New Haven Hospital
New Haven, Connecticut, United States, 06510
Actively Recruiting
Research Team
S
Stephanie Perez, MS, BS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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