Study of Rhinovirus Infection to Understand Flare-ups and Immune Responses in Adults with Bronchiectasis

What this Trial Is About

This research aims to understand if a common cold virus, specifically Rhinovirus A-16, causes flare-ups in people with bronchiectasis, a chronic lung condition affecting many individuals. It will compare responses between bronchiectasis patients and healthy participants to explore differences in immune reactions and factors like lung microbiota that might influence infection risk. The study seeks to clarify why bronchiectasis patients may be more vulnerable to viral infections and how exacerbations develop. All participants will receive a nasal spray containing Rhinovirus A-16. Before this, they will undergo screening and baseline tests including blood work, lung function tests, and bronchoscopy. After viral exposure, they will have multiple visits over six weeks with procedures such as spirometry, nasal and sputum sampling, blood tests, and repeat bronchoscopies. Participants will keep daily symptom diaries throughout the study. Participants will have detailed assessments at screening, baseline, and several follow-up visits up to 42 days post-inoculation. Tests include lung function FEV1, FVC, PEF, FeNO, blood sampling, nasal lavage and brushing, sputum collection, chest x-rays, and stool samples. Researchers will monitor symptom scores and immune responses to measure the impact of viral infection. The study includes 18 bronchiectasis patients with chronic Pseudomonas infection, 18 bronchiectasis patients without, and 18 healthy volunteers.

A Rhinovirus Challenge Study to Investigate Exacerbations and Immune Responses in Bronchiectasis