Actively Recruiting
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
Led by I.M. Sechenov First Moscow State Medical University · Updated on 2024-10-22
40
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Single-center, double-blind, randomized, controlled intervention study of the effect of correction of bacterial overgrowth syndrome in the small intestine (SIBO) on cardiac function in patients with heart failure with preserved ejection fraction (HFpEF) (SIBO-HFpEF). The aim of the study is to evaluate the efficacy and safety of rifaximin in patients with HFpEF and SIBO.
CONDITIONS
Official Title
Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent to participate in the study
- Adults aged 18 to 80 years
- Body mass index of 25 kg/m2 or higher
- Diagnosed with heart failure with preserved ejection fraction (HFpEF), including symptoms or signs of heart failure, left ventricular ejection fraction of 50% or higher, increased natriuretic peptide levels (NTproBNP 6 125 pg/mL), and at least one additional heart-related criterion such as left ventricular hypertrophy, left atrial enlargement, or diastolic dysfunction
You will not qualify if you...
- Patient refusal to continue participation in the study
- Presence of severe diseases or conditions making monitoring difficult or data interpretation unreliable, such as gastrointestinal bleeding or recent myocardial infarction
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Moscow
Moscow, Russia
Actively Recruiting
Research Team
K
Konstantin Ivashkin
CONTACT
E
Elena Bueverova
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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