Actively Recruiting
Rifaximin SSD in Dementia Trial
Led by Jasmohan Bajaj · Updated on 2026-04-03
20
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
J
Jasmohan Bajaj
Lead Sponsor
B
Bausch Health Americas, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Using a new formulation of rifaximin, a non-absorbable antibiotic, to test if it can affect microbes in the gut of patients with dementia favorably.
CONDITIONS
Official Title
Rifaximin SSD in Dementia Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Probable Alzheimer's Disease or Vascular Dementia, mild or moderate, based on Clinical Dementia Rating Scale
- Male or female aged 65 years or older
- Living in the community with a caregiver available to accompany to study visits and participate
- Able to consent or have a legal guardian who can consent, with participant assent
- Legal representative and caregiver are the same person
- Both participant and caregiver are fluent in written and spoken English
You will not qualify if you...
- Dementia not due to Alzheimer's Disease or Vascular Dementia
- Clinically significant agitation or aggression needing antipsychotic medication
- Presence of delusions or hallucinations
- Severe psychiatric conditions including major depression
- Unstable, severe, or poorly controlled medical conditions
- Visual or hearing disorders preventing neuropsychologic testing
- Diarrhea
- Allergy to rifaximin, rifaximin components, or any rifamycin antimicrobial
- Antibiotic use within the past 6 months
- Taking medications that interact with rifaximin (except P-glycoprotein inhibitors if discussed with investigator)
- History of alcohol or drug abuse
- Participation in another investigational drug trial within the last 30 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Richmond VA Medical Center
Richmond, Virginia, United States, 23249
Actively Recruiting
Research Team
J
Jasmohan S Bajaj, MD
CONTACT
H
Haley Obolewicz, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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