Actively Recruiting
Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease
Led by University of Colorado, Denver · Updated on 2026-05-08
60
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
Sponsors
U
University of Colorado, Denver
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
CONDITIONS
Official Title
Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of COPD confirmed by FEV1/FVC ratio less than 0.7
- Age 40 years or older
You will not qualify if you...
- COPD exacerbation within 3 months before enrollment
- Change in COPD treatment within 3 weeks before enrollment
- Need for more than 6 liters per minute supplemental oxygen at rest
- Need for more than 10 liters per minute supplemental oxygen during exercise
- Active or uncontrolled cardiovascular disease such as uncontrolled hypertension, angina, low left ventricular ejection fraction (40% or less), arrhythmia, or significant heart valve problems
- Signs of fluid overload like jugular vein swelling or peripheral edema greater than trace
- World Health Organization Functional Class IV
- Known pulmonary hypertension with mean pulmonary artery pressure over 45 mmHg
- Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
- Active cancer (except skin cancer)
- Medical conditions preventing exercise on a stationary bike (e.g., severe osteoarthritis, balance or gait problems)
- Pregnancy
- Body mass index less than 18 or greater than 35
- Hematocrit less than 25% or greater than 55%
- For those undergoing right heart catheterization, chronic anticoagulation that cannot be paused
- For catheterization or exercise training subset, forced expiratory volume in 1 second below 20%
- For exercise training, already doing routine exercise training more than 30 minutes at more than 3 METs three or more times per week
- For exercise training, unable to complete initial in-person sessions of about 35 minutes three times per week for 3 weeks
- For remote exercise training option, medical conditions that make remote exercise unsafe (e.g., balance or gait instability)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
Research Team
L
Lindsay Forbes, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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