Safety Study of Targeted Spinal Cord Radiation for Adults with Metastatic Epidural Spinal Cord Compression Using Spine Stereotactic Radiosurgery

What this Trial Is About

Researchers are evaluating the safety of a procedure called cord dose escalated spine stereotactic radiosurgery CDE-SSRS in patients with metastatic epidural spinal cord compression MESCC. This study specifically aims to keep the risk of non-functional paresis, defined by the McCormick score as Grade D, at no greater than 1%. Secondary goals include assessing pain control, quality of life, symptom burden, overall survival, toxicity, walking ability, and cost-effectiveness using various patient questionnaires and MRI scans. The treatment involves a non-invasive, precise radiation procedure called stereotactic radiosurgery given in a single session. This radiation targets cancer in the spine while avoiding surrounding healthy tissue. The radiation dose is carefully adjusted based on the tumors proximity to the spinal cord or cauda equina to achieve effective treatment while protecting critical areas. Participants must have up to three contiguous vertebral levels involved and be able to receive the planned radiation dose safely. Participants will be monitored through regular MRI scans and assessments including pain inventories and quality of life questionnaires. Researchers will track safety and adverse events during the study, which spans an average of one year. The study involves signing informed consent and includes evaluations of motor strength and functional status. The study is sponsored by M.D. Anderson Cancer Center and started in November 2024, continuing through December 2029.

Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery