Actively Recruiting

Phase 2
Age: 18Years +
All Genders
NCT06204315

Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery

Led by M.D. Anderson Cancer Center · Updated on 2026-04-16

60

Participants Needed

1

Research Sites

268 weeks

Total Duration

On this page

Sponsors

M

M.D. Anderson Cancer Center

Lead Sponsor

B

Brainlab AG

Collaborating Sponsor

AI-Summary

What this Trial Is About

To learn about the safety of a procedure called cord dose escalated spine stereotactic radiosurgery (CDE-SSRS) in patients with MESCC.

CONDITIONS

Official Title

Risk Adapted Spinal Cord/Cauda Constraint Relaxation for High-risk Patients With Metastatic Epidural Spinal Cord Compression Undergoing Spine Stereotactic Radiosurgery

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • 18 years old or older
  • Radiographically confirmed spinal metastasis on MRI within 4 weeks of registration
  • Spinal metastasis near spinal cord or cauda equina preventing minimum tumor dose of 14 Gy
  • Able to receive single session spine stereotactic radiosurgery with specified dose limits to spinal cord (14-16 Gy) and/or cauda equina (18-20 Gy)
  • Maximum of 3 contiguous vertebral levels involved to be treated in one session
  • Able to receive at least 18 Gy single fraction spine radiosurgery at target site
  • Vertebral site of interest between C1 and S2
  • Signed informed consent
  • Diagnosis of cancer excluding ultra-radiosensitive types (lymphoma, multiple myeloma/plasmacytoma)
  • Motor strength of 4 or higher out of 5 in affected extremity or extremities
  • ECOG performance status of 2 or less
Not Eligible

You will not qualify if you...

  • Ultra-radiosensitive cancer types (lymphoma, multiple myeloma/plasmacytoma)
  • Prior radiation at the spinal site of interest
  • Unable to lie supine comfortably for at least 60 minutes
  • Progressive neurological deficits due to compression
  • Unable to obtain or refusal to undergo MRI or MR simulation
  • Not eligible for single fraction spine stereotactic radiosurgery for any reason
  • Pregnant participants

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

MD Anderson Cancer Center

Houston, Texas, United States, 77030

Actively Recruiting

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Research Team

A

Amol Ghia, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

SUPPORTIVE_CARE

Number of Arms

1

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