Actively Recruiting
Risk Factors Affecting MSC Efficacy in ACLF Patients
Led by Sun Yat-sen University · Updated on 2025-11-28
446
Participants Needed
1
Research Sites
36 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Mesenchymal stromal cells (MSCs) are potential therapy for many diseases, with the ability of tissue regeneration, repair and immunomodulation. Acute-on-chronic liver failure (ACLF) is a severe disease with high mortality. Previous studies showed that MSCs can improve the outcomes of Hepatitis B virus (HBV)-related ACLF patients. However, there are still some ACLF patients who have not benefited from MSC treatment. Thus, searching for risk factors affecting MSC efficacy in ACLF patients is of great significance for promotion of MSCs therapy. This retrospective study will perform at a single center in southern China. Consecutive HBV related-ACLF patients treated with MSCs at the Third Affiliated Hospital of Sun Yat-sen University from January 2010 to October 2018 will be included. The clinical data including survival status, liver functions, complications et al. will be collected and analyzed, with the purpose of identifying the risk factors of HBV-related ACLF patients received MSCs injection and improving the efficacy of MSCs therapy furtherly.
CONDITIONS
Official Title
Risk Factors Affecting MSC Efficacy in ACLF Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of acute-on-chronic liver failure
- Positive serum HBV surface antigen for more than 6 months
- Received MSCs infusion more than one time
You will not qualify if you...
- Systemic or local malignancy
- Hepatitis C virus infection
- HIV infection or other immunodeficiency disease
- Marked organ dysfunction (e.g., renal dysfunction)
- Pregnancy or lactation
- Hyperthyroidism or other primary thyroid diseases
- Incomplete data or lost to follow-up
- Hospital stay < 1 day
AI-Screening
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Trial Site Locations
Total: 1 location
1
Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China, 510630
Actively Recruiting
Research Team
D
Dr. Chen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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