Study of Risk Factors for Carbapenem-Resistant Enterobacteriaceae in Children Hospitalized in the Pediatric ICU

What this Trial Is About

This research focuses on children hospitalized in the Pediatric Intensive Care Unit PICU at Childrens Hospital of Fudan University between January 2018 and December 2019. It aims to understand the risk factors and microbiologic characteristics of infections or colonization with Carbapenem-Resistant Enterobacteriaceae CRE, a group of bacteria resistant to certain antibiotics. The study is retrospective, reviewing past medical records to gather data on this serious infection in a high-risk pediatric population. Children in the study are grouped based on their clinical culture results during their PICU stay those without CRE, those colonized with CRE but without symptoms, and those infected with CRE showing clinical symptoms. CRE is defined according to CDC criteria as bacteria resistant to specific antibiotics like imipenem, meropenem, or ertapenem. The study collects clinical and demographic data from electronic health records to analyze these groups. Participants involvement includes reviewing medical records to track outcomes such as mortality within 28 days after PICU discharge and the length of PICU stay within the same period. The study does not involve new treatments but monitors past hospital data to identify factors linked to CRE colonization or infection. The research extends over a timeframe from January 2018 to December 2019 and is sponsored by Childrens Hospital of Fudan University.

Risk Factors for Colonization or Infection With Carbapenem-Resistant Enterobacteriaceae in Children