Study on Risk of New Advanced Lesions After Delayed Surveillance in Patients With Serrated Lesions or High-grade Dysplasia From Colonoscopy

What this Trial Is About

Researchers are investigating the risk of developing new advanced colorectal lesions after detecting serrated lesions SLs such as sessile serrated polyps and traditional serrated adenomas, as well as high-risk adenomas following high-grade dysplasia HGD found during initial colonoscopy. The study focuses on patients who experienced delays in follow-up colonoscopies to understand how interruptions in care may affect the detection of advanced lesions and colorectal cancer. This research addresses differing guidelines on surveillance timing and aims to clarify optimal intervals for repeat colonoscopies in these patients. Participants will undergo a standard colonoscopy, during which all visually identified polyps will be removed and analyzed by pathology according to institutional procedures. The study includes patients diagnosed with SL or HGD from 2010 to 2022 who lacked timely follow-up. These patients will be contacted and invited for follow-up colonoscopy as part of routine clinical care to assess the occurrence of new lesions after delayed surveillance. Throughout the study, data collected will include patient demographics, medical and family history, colonoscopy details such as indication, bowel preparation quality, withdrawal time, polyp characteristics, and any complications. Researchers will measure rates of new advanced neoplasia and high-risk adenomas detected within one year after the initial diagnosis. This detailed evaluation aims to understand risks associated with surveillance delays and improve continuity of care for affected patients.

Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay