Actively Recruiting
Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
Led by Fu Wai Hospital, Beijing, China · Updated on 2026-01-05
10000
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating how coronary artery disease develops and progresses in young adults aged 45 years or younger. This nationwide study in China aims to collect detailed health information from about 10,000 participants who have coronary CT scans at several hospitals. The goal is to better understand risk factors for disease progression and create models to predict future coronary plaque growth and cardiovascular events. Participants will have a baseline coronary CT scan and provide information on health, cardiovascular risks, blood tests, medication use, lifestyle habits, and genetic data when available. After several years, follow-up coronary CT scans will be done to assess changes in coronary artery plaque and disease progression. This observational study does not involve any treatment interventions. During the study, participants will undergo health assessments and coronary CT scans at enrollment and follow-up visits, up to 3 years later. Researchers will measure the progression of coronary plaque using computed tomography and analyze clinical data to identify factors linked to disease advancement. The study is sponsored by Fu Wai Hospital in Beijing and aims to improve early prevention and risk assessment for young adults with coronary artery disease.
CONDITIONS
Brief Title
Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years at the time of enrollment
- Presence of symptoms suggestive of coronary artery disease
- Completion of coronary computed tomography (CT) examination
- Ability and willingness to provide written informed consent
- Willingness to participate in follow-up assessments
You will not qualify if you...
- Inability or unwillingness to complete follow-up assessments
- Inability to provide written informed consent
- History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting
- Poor-quality coronary computed tomography images inadequate for reliable plaque assessment
- Severe systemic disease with limited life expectancy interfering with follow-up
- Pregnant or breastfeeding women
- Participation in another clinical study that may interfere with study outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline
Participants complete coronary computed tomography (CT) examinations to assess coronary plaque.
1 visit (in-person)
Duration - Up to 3 years
Participants are followed over time to monitor progression of coronary plaque through follow-up coronary CT scans.
Follow-up visits for coronary CT assessments up to 3 years
Trial Site Locations
Total: 1 location
1
FuWai hospital
Beijing, China, 100000
Actively Recruiting
Research Team
Z
Zhihui Hou, MD, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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