Actively Recruiting
Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study
Led by M.D. Anderson Cancer Center · Updated on 2026-04-15
100
Participants Needed
9
Research Sites
241 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective preference study that will evaluate non-inferiority of the innovative treatment (RRS with delayed RRO) as compared to the standard treatment (RRSO) with respect to high grade serous (ovarian) cancer incidence
CONDITIONS
Official Title
Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Premenopausal women with a documented harmful mutation in BRCA1, BRCA2, BRIP1, RAD51C, PALB2, or RAD51D genes
- Age 25 to 40 years for BRCA1 mutation carriers
- Age 25 to 45 years for BRCA2 mutation carriers
- Age 30 to 50 years for BRIP1, RAD51C, RAD51D, and PALB2 mutation carriers
- No longer need fallopian tubes for natural childbearing; future plans for IVF allowed
- Have at least one fallopian tube present
- May have a personal history of non-ovarian cancer
- Able to provide informed consent
You will not qualify if you...
- Postmenopausal status, natural or due to cancer treatment
- Plan to have risk-reducing oophorectomy within two years after salpingectomy, if known at enrollment
- Legally incapable of giving consent
- Previous bilateral salpingectomy
- Personal history of ovarian, fallopian tube, or peritoneal cancer
- Current signs, diagnosis, or treatment for cancer (except use of Aromatase Inhibitors, Tamoxifen, or Selective Estrogen Receptor Modulators are allowed)
AI-Screening
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Trial Site Locations
Total: 9 locations
1
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
2
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
3
WU St Louis
St Louis, Missouri, United States, 63130
Actively Recruiting
4
Mount Sinai Health System
New York, New York, United States, 10029
Actively Recruiting
5
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
6
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
7
Lyndon Baines Johnson General
Houston, Texas, United States, 77026
Actively Recruiting
8
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
9
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
R
Roni Wilke, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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