Actively Recruiting
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals
Led by Vanderbilt University Medical Center · Updated on 2026-03-10
150
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pulmonary arterial hypertension (PAH) is a severe disease with a delayed diagnosis and markedly elevated mortality. High-risk populations, such as those with known genetic defects, provide a unique opportunity to determine the features of susceptibility and resilience to PAH. This proposal will fundamentally overturn the prevailing understanding of PAH by creating molecularly-driven signatures of susceptibility and resilience, provide novel insight into disease severity, and potentially identify new therapeutic targets. Funding Source - FDA OOPD
CONDITIONS
Official Title
Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children and adults aged 15 to 80 years
- Diagnosed with idiopathic or heritable pulmonary arterial hypertension (PAH) based on standard criteria
- Unaffected mutation carriers: healthy individuals with a known BMPR2 gene mutation and normal pulmonary pressure and right ventricular function on echocardiogram
- Healthy controls without cardiopulmonary disease
- WHO functional class I to III
- Stable PAH-specific medication regimen for at least three months before enrollment, allowing only a single diuretic adjustment or IV prostacyclin adjustments for side effects
You will not qualify if you...
- Unable to perform normal activities due to wheelchair, bed bound status, use of cane/walker, or activity-limiting conditions like angina or osteoarthritis
- Pregnancy
- PAH caused by other known etiologies besides idiopathic or heritable
- Functional class IV heart failure
- More than two diuretic adjustments within the three months prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
K
Kelly Burke, RN
CONTACT
A
Alisha Lindsey, RT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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