Actively Recruiting
Rituximab for Serious Aplastic Anemia With Platelet Transfusion Refractoriness
Led by Institute of Hematology & Blood Diseases Hospital, China · Updated on 2024-02-12
20
Participants Needed
1
Research Sites
253 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Due to long-term dependence on platelet transfusion, some severe aplastic anemia (SAA) patients suffer platelet transfusion refractoriness (PTR). Unlike immune thrombocytopenia (ITP), glucocorticoids and human immunoglobulin (IVIg) are generally ineffective for PTR. Due to the lack of effective intervention methods, patients with PTR suffer increased platelet transfusions, bleeding events and treatment costs, prolonged hospital stays, and decreased survival rate. SAA with PTR has become a challenge for physicians. The experiment aims to explore the efficacy of rituximab in the treatment of SAA with PTR, and establish a new effective, safe treatment method with relatively low treatment cost.
CONDITIONS
Official Title
Rituximab for Serious Aplastic Anemia With Platelet Transfusion Refractoriness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Initial diagnosis of severe aplastic anemia with platelet transfusion refractoriness
- Age greater than 18 years
- Any gender
You will not qualify if you...
- Allergy to rituximab
- Severe active infection
- Hypogammaglobulinemia
- Pregnant or breastfeeding women
- Heart failure classified as NYHA IV
- Epilepsy, dementia, or other mental disorders requiring medication that impair understanding or compliance
- Chronic infections or other chronic diseases posing risk to the study
- Researchers' judgment deeming participation unsuitable
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, China, 300020
Actively Recruiting
Research Team
H
Huang Jinbo, MD.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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