Actively Recruiting
Rivaroxaban in Elderly Chinese Venous Thromboembolism Patients
Led by Peking Union Medical College Hospital · Updated on 2024-01-08
300
Participants Needed
1
Research Sites
286 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There's no unified recommendation in clinical practice regarding adjusting dosages for different patient types, especially when adverse events occur. While rivaroxaban typically doesn't require coagulation monitoring, in elderly patients, particularly those with multiple medications, finding appropriate lab indicators becomes crucial to gauge its anticoagulant effect. This aids in evaluating precise rivaroxaban dosing for the elderly, balancing bleeding risks and recurrence. Clinical pharmacological studies suggest that drug pharmacokinetics and pharmacodynamics in different populations can guide dosage optimization. Hence, this study aims to provide a basis for optimizing dosing regimens in high-risk elderly patients in China by exploring pharmacokinetic and pharmacodynamic indicators in clinical practice.
CONDITIONS
Official Title
Rivaroxaban in Elderly Chinese Venous Thromboembolism Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with acute symptomatic pulmonary embolism diagnosed by imaging, with or without deep vein thrombosis, who have completed acute anticoagulation and entered maintenance phase
- Life expectancy longer than 3 months
- Meet indications for Xa factor inhibitor use
- Willing to participate, sign informed consent, and attend regular follow-ups
You will not qualify if you...
- Moderate or severe liver impairment (Child-Pugh Class B or C)
- Severe kidney impairment (creatinine clearance less than 15 mL/min)
- Pregnant or breastfeeding women
- Spontaneous bleeding tendencies such as coagulation disorders or low platelet count (less than 20 x 10^9/L)
- Contraindications to Xa factor inhibitors
- Diagnosed hereditary thrombophilia or antiphospholipid syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China, 100730
Actively Recruiting
Research Team
J
juhong Shi, M.D
CONTACT
M
min Peng, M.D
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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