Actively Recruiting
RM1 Project 2 - tAN fMRI
Led by Medical University of South Carolina · Updated on 2025-12-18
96
Participants Needed
1
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this one-visit, randomized, double-blind, sham-controlled trial, we plan to use a novel concurrent transcutaneous auricular neurostimulation (tAN) paradigm during functional magnetic resonance imaging (fMRI) paradigm in 96 individuals to determine whether tAN administered to two cranial nerves simultaneously produces greater neurophysiologic effects than stimulating solely to the auricular branch of the vagus nerve (ABVN) or the auriculotemporal nerve (ATN; branch of trigeminal nerve) alone. Within the MRI scanner, each participant will be connected to a series of electrodes that stimulate 4 targets (ABVN only, ATN only, ABVN plus ATN, and Sham).
CONDITIONS
Official Title
RM1 Project 2 - tAN fMRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65
- Have the capacity and ability to provide one's own consent and sign the informed consent document
You will not qualify if you...
- Contraindicated for MRI
- Any current or recent untreated medical, neurological, or psychiatric conditions
- Metal implant devices in the head, heart or neck
- History of brain surgery
- History of myocardial infarction or arrhythmia, bradycardia
- Personal or family history of seizure or epilepsy or use of medications that reduce seizure threshold
- Personal history of head injury, concussion, or moderate to severe traumatic brain injury
- Frequent or severe headaches
- History of psychosis or mania, or currently manic or psychotic
- Moderate to severe alcohol or substance use disorder
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of South Carolina Institute of Psychiatry
Charleston, South Carolina, United States, 29425
Actively Recruiting
Research Team
B
Bashar Badran, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
5
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