Actively Recruiting
RNS for Treatment-resistant Obsessive-compulsive Disorder
Led by Xuanwu Hospital, Beijing · Updated on 2025-01-20
10
Participants Needed
1
Research Sites
255 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant obsessive-compulsive disorder (TR-OCD).
CONDITIONS
Official Title
RNS for Treatment-resistant Obsessive-compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 65 years
- Able to provide written informed consent
- Diagnosed with obsessive-compulsive disorder (OCD) according to DSM-IV-TR and confirmed by Mini-International Neuropsychiatric Interview
- Have not improved after two distinct courses of selective serotonin reuptake inhibitors (SSRIs), each lasting 3 to 6 months
- Have not improved after maximum dose of clomipramine for 3 to 6 months in a single trial
- Have not improved after cognitive behavior therapy for six months
- Have not improved after three months of atypical antipsychotic medications alone or combined with SSRIs or clomipramine
You will not qualify if you...
- Presence of other psychotic disorders
- History of treatments including electroconvulsive therapy (ECT), modified ECT, transcranial direct or alternating current stimulation, deep brain stimulation (DBS), or transcranial magnetic stimulation (TMS)
- Suicide risk defined as a HAMD-17 score of 3 or higher on suicide-related items
- Difficulty communicating effectively with investigators
- History of traumatic brain injury (TBI)
- Presence of intracranial or cardiovascular stents
- Substance abuse within the past six months
- Unstable neurological or coagulation disorders
- Women who are pregnant, lactating, or of childbearing potential who refuse reliable contraception during the study
- Participation in other clinical studies within three months before enrollment
- Any condition deemed unsuitable for the study by the research team
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, China, 100053
Actively Recruiting
Research Team
H
Hongxing Wang, MD & PhD
CONTACT
H
Huang Wang, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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