Study of Rod and Cone Photoreceptor Function and Vision in Low Light Conditions Comparing People With and Without Retinal Disease

What this Trial Is About

Researchers are investigating how rod and cone photoreceptors function in the eyes of healthy people and those with retinal diseases such as Retinal Degeneration, Retinitis Pigmentosa, and Stargardts Disease. The study aims to determine whether a persons ability to see in low light can serve as a test for the severity of retinal disease, helping detect and monitor changes over time. This observational, case-control study involves up to 500 participants aged five and older. Participants with retinal disease and healthy volunteers undergo a variety of vision tests. These include eye exams, imaging with dilated pupils, visual field tests where participants respond to light stimuli, and electroretinograms ERG to measure retinal signals after dark adaptation. The study uses specialized devices to assess dark adaptation speed, retinal sensitivity, and hyperacuity under low light. Some participants complete patient questionnaires on vision under dim conditions, and a subgroup with retinal disease will have additional ERG sessions to compare with historical clinical data. During visits lasting from 3 to 8 hours, participants undergo eye exams, imaging, and tests of their ability to detect colored light in dark conditions over periods ranging from 5 to 45 minutes. Up to 6 follow-up visits occur over 6 to 12 months to monitor changes. Researchers measure outcomes like dark adaptation kinetics, retinal sensitivity, and hyperacuity, correlating these with patient-reported vision difficulties. The study also aims to establish normal ranges for these measures and develop scaling factors for ERG results. Overall participation may last up to 5 years with multiple visits to track vision changes.

Rod and Cone Mediated Function in Retinal Disease