Actively Recruiting
Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients
Led by Tanta University · Updated on 2026-05-04
60
Participants Needed
1
Research Sites
128 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Major depressive disorder (MDD) is one of the most common psychiatric disorders with serious socioeconomic consequences on daily life and health care costs. Despite the advent of newer antidepressants that target monoamine pathways, nearly 50% of patients have no response to first-line antidepressant therapy. Thus, a combination of medications with different strategies at the beginning of treatment could provide further therapeutic benefits to MDD patients
CONDITIONS
Official Title
Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged over 18 years old
- Patients with a Hamilton Depression Rating Scale (Ham-D) score of at least 18, with a depressed mood item score of 2 or greater
You will not qualify if you...
- Patients with bipolar I or bipolar II disorder; eating disorders; personality disorders; mental retardation; current anxiety disorders (except specific phobia)
- Patients with mental disorder due to general medical condition
- Patients with substance dependence or abuse in the previous three months
- Patients with concurrent medical illness or history of seizures that contraindicate study medication
- Patients receiving Electroconvulsive therapy (ECT)
- Pregnant women or women not using medically accepted birth control
- Patients scoring greater than 2 on the suicide item of the Ham-D or judged to have significant suicidal ideation
- Patients required to be free of all psychotropic medications except escitalopram and anti-inflammatory drugs for at least four weeks before study entry
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tanta Unuversity
Tanta, Egypt, 31527
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here