Actively Recruiting
Role of Aging and Individual Variation in Exercise Training Responsiveness
Led by Duke University · Updated on 2025-11-14
26
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
D
Duke University
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 26 participants to complete a 6-month aerobic exercise intervention.
CONDITIONS
Official Title
Role of Aging and Individual Variation in Exercise Training Responsiveness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals who completed participation in the STRRIDE-PD trial (NCT00962962)
- Body Mass Index (BMI) > 18 and < 45 kg/m2
- Stable dose (61 month) of any cardiometabolic medications
You will not qualify if you...
- Poor vein access
- Current use of tobacco or any nicotine products, including e-cigarettes
- Insulin-dependent diabetes
- Active untreated hypothyroidism with thyroid stimulating hormone (TSH) concentrations > 10.0 uIU/mL
- Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
- Current, actively treated malignancy other than dermatologic conditions
- Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
- Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
- Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures >160/90 mmHg
- Unable to safely participate in an exercise program per study protocol per PI discretion
- Planned, intentional weight loss during study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Duke Center for Living
Durham, North Carolina, United States, 27705
Actively Recruiting
Research Team
J
Johanna L Johnson, MS
CONTACT
L
Leanna M Ross, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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