Actively Recruiting
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)
Led by Monash University · Updated on 2025-10-07
900
Participants Needed
3
Research Sites
99 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an adaptive platform study to find out how safe and effective different strategies are in comparison to each other, for preventing infection in patients with blood cancers. It is a comparison between Immunoglobulin and antibiotics use.
CONDITIONS
Official Title
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy Platform Trial (RATIONAL-PT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Diagnosis of blood cancer including chronic lymphocytic leukemia, multiple myeloma, or non-Hodgkin's lymphoma
- Eligible for or currently receiving intravenous or subcutaneous immunoglobulin replacement due to history of recurrent or severe infections and low IgG levels
- Life expectancy greater than 12 months
- Able to provide informed consent
You will not qualify if you...
- Treating medical team believes participation is not in the patient's best interest
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 3 locations
1
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Actively Recruiting
2
Austin Hospital
Melbourne, Victoria, Australia, 3004
Actively Recruiting
3
Northern Health
Melbourne, Victoria, Australia, 3004
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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