Actively Recruiting
The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery
Led by University of Michigan · Updated on 2025-03-19
300
Participants Needed
1
Research Sites
791 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Antibiotics are sometimes prescribed to patients who have had reconstructive surgery of wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve the healing of skin grafts and reduce the risk of infections after surgery in these patients. It is known that antibiotics, like all medications, have side-effects although these are rare. This research study is designed to show us whether antibiotics improve wound healing or not, so that we may determine if we should continue using antibiotics even if they have side-effects in some patients. Our hypothesis is that patients treated with post-operative, systemic antibiotics will demonstrate a statistically significant improvement in the survival of their facial full thickness skin grafts compared to patients who are not treated with systemic antibiotics.
CONDITIONS
Official Title
The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with nasal or facial skin or soft tissue defects requiring reconstruction with a full-thickness skin graft
You will not qualify if you...
- Current or recent (within one week) use of systemic antibiotics
- Allergy or intolerance to both clindamycin and cephalexin
- Discovery of ongoing skin cancer at the defect site after surgery
- Previous reconstructive surgery at the defect site
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
J
Jeffrey S Moyer, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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