Actively Recruiting
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Led by Medical College of Wisconsin · Updated on 2025-10-30
60
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.
CONDITIONS
Official Title
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants must be between 18 and 80 years old
- Have a clinical diagnosis of Type 2 Diabetes Mellitus according to American Diabetes Association guidelines or be otherwise healthy with no more than one cardiovascular risk factor
You will not qualify if you...
- Uncontrolled hypertension
- Current tobacco use or tobacco use within the last 6 months
- Body mass index (BMI) greater than 35
- Hyperlipidemia or hypercholesterolemia
- Diagnosis of Type 1 Diabetes
- Use of anti-coagulant or anti-platelet drugs
- Symptomatic coronary artery disease
- Heart failure
- Renal impairment
- Use of hormone replacement therapy
- History of retinopathy
- Documented neuromuscular disorders
- Porphyria Cutanea Tarda (skin blistering and photosensitivity)
- Pregnancy (in young female subjects)
- Allergies to povidone iodine
- Use of erectile dysfunction medication in the past 6 months
- Use of topical or non-topical steroids in the last 6 months
- Active anti-cancer treatment or treatment within the last 12 months
- Active COVID-19 or COVID-19 within the past 3 months
- Gender reassignment therapy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
W
William Hughes, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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