Actively Recruiting
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Led by University of Florida · Updated on 2026-02-06
275
Participants Needed
3
Research Sites
192 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.
CONDITIONS
Official Title
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Blunt trauma with injury severity score greater than 15 and a long bone or pelvic fracture requiring open reduction internal fixation or intramedullary fixation
- Blunt trauma patients with shock, defined by systolic blood pressure less than 90 mm Hg, base deficit of 5 meq or more, lactate 2 mmol/L or more, or active red blood cell or whole blood transfusion within 6 hours of arrival
- Adults aged 55 years or older undergoing elective hip repair for non-infectious reasons
- Ability to provide informed consent prior to operation
You will not qualify if you...
- Patients not expected to survive more than 48 hours
- Prisoners
- Pregnancy
- Previous bone marrow transplantation
- Patients receiving chronic corticosteroids or immunosuppression therapies
- Patients with end stage renal disease
- Patients with any pre-existing hematological disease
- Surgery for injury repair more than seven days after hospital admission for trauma
- Burn injury covering more than 20% total body surface area
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
UF Academic Research Building
Gainesville, Florida, United States, 32610
Actively Recruiting
2
UF Health at Shands Hospital
Gainesville, Florida, United States, 32610
Actively Recruiting
3
UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
R
Ruth Davis, BSN
CONTACT
J
Jennifer Lanz, MSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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