Actively Recruiting
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2024-10-15
380
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome. * Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans
CONDITIONS
Official Title
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Informed consent from the patient or a legal representative, with the patient asked to consent when able
- Affiliation to social security (AME excluded)
- Diagnosis of one of the following circulatory failures: septic shock, cardiogenic shock, or post-resuscitation syndrome
- For cardiogenic shock: need for catecholamine support to keep mean arterial pressure above 65 mmHg, cardiac index below 2 L/min/m2 or left ventricular ejection fraction below 35%, and lactate above 2.0 mmol/l
- For post-resuscitation syndrome: cardiac arrest with compatible ECG, need for catecholamine support to keep mean arterial pressure above 65 mmHg, and lactate above 2.0 mmol/l
- For septic shock: suspected or proven bacterial infection, need for vasopressor support to keep mean arterial pressure above 65 mmHg, lactate above 2.0 mmol/l, and cardiac index above 3 L/min/m2 or left ventricular ejection fraction above 40%
You will not qualify if you...
- Shock onset (catecholamine infusion) more than 12 hours before inclusion
- Age younger than 18 years
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hôpital Européen Georges Pompidou
Paris, France, 75015
Actively Recruiting
Research Team
N
Nicolas BRECHOT, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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