Actively Recruiting
Role of Coenzyme Q10 in Chronic Kidney Disease
Led by Tanta University · Updated on 2025-06-19
44
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This randomized placebo controlled double blind parallel clinical study will be conducted on 44 non-dialysis chronic kidney disease (CKD) patients (Stages 2-3b).Clinical Study Evaluating the Role of Coenzyme Q10 as Adjuvant Therapy to Angiotensin Converting Enzyme Inhibitor on Blood Pressure, Proteinuria and Bone Metabolism in Patients with Chronic Kidney Disease. Patients will be recruited from, Internal Medicine Department, Nephrology Unit, Alexandria Main University Hospital, Egypt. Patients with albumin-to-creatinine ratio ≥ 30 mg/g, with serum Potassium \< 5 mEq/L and newly diagnosed patients with hypertension. The study duration will be 6 months. The patients will be randomized using stratified random block method into two groups. Group 1: Control group Non-dialysis chronic kidney disease (CKD) patients (Stages 2-3b). Patients will be treated with ramipril 10 mg/day and a placebo match Coenzyme Q10 capsules once per day.The dose of ramipril may be modified according to blood pressure control. Group 2: Coenzyme Q10 Non-dialysis chronic kidney disease (CKD) patients (Stages 2-3b).Patients will be treated with ramipril 10 mg/day and Coenzyme Q10 capsules (CoQ10) 200 mg/day. The dose of ramipril may be modified according to blood pressure control. Participants will be followed-up by weekly telephone calls and monthly direct meetings to assess their adherence for 6 months.
CONDITIONS
Official Title
Role of Coenzyme Q10 in Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Any gender
- Matched in duration of chronic kidney disease
- Non-dialysis CKD patients with estimated glomerular filtration rate (GFR) between 30-89 mL/min/1.73m2 (Stage 2-3b)
- Albumin-to-creatinine ratio of 30 mg/g or higher
- Serum potassium less than 5 mEq/L
- Newly diagnosed with hypertension
You will not qualify if you...
- Potassium level 5 mEq/L or higher
- Diabetes
- Cancer
- Heart disease
- Hepato-biliary or other liver diseases
- Kidney stones or urinary tract infection
- Overactive thyroid gland
- Bleeding disorders
- History of allergy to ACE inhibitors or ARBs
- Pregnant or breastfeeding women
- Blood pressure 180/110 mmHg or higher, or below 100/60 mmHg
- Use of certain medications including alteplase, azathioprine, everolimus, sirolimus, lithium, non-steroidal anti-inflammatory drugs, potassium-retentive diuretics, other ACE inhibitors or ARBs
- Use of omega-3 fatty acids, vitamins A, C, E, K, chemotherapy, oral anticoagulants, cholestyramine, or orlistat due to possible drug interactions affecting Coenzyme Q10
AI-Screening
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Trial Site Locations
Total: 1 location
1
Faculty of Pharmacy Tanta University
Tanta, Capital of Gharbia Governorate., Egypt, 31527
Actively Recruiting
Research Team
D
Dina Abdel Hamid, Masters
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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