Actively Recruiting
The Role of Cxcr4Hi neutrOPhils in InflueNza
Led by University Hospital, Bordeaux · Updated on 2024-12-27
90
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Influenza is still responsible for more than 650,000 deaths per year worldwide and no major improvements in patients' care has been made despite 50 years of research. Especially, there is no therapeutic strategy targeting the dysregulated host response. CXCR4-expressing neutrophils seem to be involved in the rupture of host resistance. The aim of this study is thus to compare the percentage of blood CXCR4-expressing neutrophils between influenza survivors and non-survivors.
CONDITIONS
Official Title
The Role of Cxcr4Hi neutrOPhils in InflueNza
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18 yo or above.
- Acute respiratory distress syndrome as defined by the Berlin classification.
- Invasive mechanical ventilation for less than 24 hours.
- Cause of ARDS: Influenza infection proven by polymerase chain reaction OR Bacterial infection (tracheal aspirate with more than 105 CFU/mL and BAL with more than 104 CFU/mL) OR Pancreatitis according to the 2013 Working Group IAP/APA Acute Pancreatitis Guidelines OR Peritonitis according to the 2018 SFAR guidelines.
- Health insurance.
- Written informed consent from legal relative or representative.
You will not qualify if you...
- Neutropenia (< 500/mm3).
- Neutrophils qualitative defect.
- Patient included in an interventional research assessing an immunomodulatory or antiviral drug.
- Acquired ImmunoDeficiency Syndrome.
- Contraindication to BAL: Severe bronshospasm, Out-of-control shock, Intracranial high pressure, Refractory hypoxemia (PaO2/FiO2 < 60 mmHg).
- Legal restriction: prisoners, pregnancy, legal protection.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Hopital Pellegrin
Bordeaux, France, 33000
Actively Recruiting
2
Hopital Haut-Lévêque
Pessac, France, 33604
Not Yet Recruiting
Research Team
R
Renaud PREVEL, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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