Comparing Echocardiography and Carotid Artery Ultrasound to Guide Fluid Treatment in Adults with Septic Shock Aged 18 to 50

What this Trial Is About

Researchers are evaluating methods to guide fluid resuscitation in critically ill patients with septic shock, a condition where blood flow is dangerously low. This study focuses on comparing carotid artery flow measurements with echocardiographic left ventricular end diastolic volume to predict which patients will respond to fluid treatment. Only about half of critically ill patients with unstable circulation respond to fluids, so accurate assessment tools are needed to improve care. The study involves two main procedures performed within 1 to 2 hours of ICU admission carotid artery duplex ultrasound and echocardiography to measure left ventricular end diastolic area LVEDA. Patients receive fluid resuscitation following guidelines, with 30 mlkg of IV crystalloid fluid given as 500 ml boluses over 15 minutes. A fluid challenge of 1000 ml Ringer acetate solution is then rapidly infused over 30 minutes. The ultrasound and echocardiography measurements are repeated after fluid infusion to see if blood flow or heart chamber size changes indicate fluid responsiveness. Participants will be monitored closely in the ICU, with ultrasound and echocardiographic assessments before and after fluid treatment. Researchers will measure the accuracy of these imaging tools within one day to predict fluid responsiveness. The study also records clinical signs of circulatory failure. Data will be collected to evaluate the effectiveness of these noninvasive techniques for guiding fluid management in septic shock patients. The total study participation duration varies depending on ICU admission and monitoring needs.

Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients