Actively Recruiting
Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
Led by University Hospital, Montpellier · Updated on 2025-10-03
1452
Participants Needed
1
Research Sites
417 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Montpellier
Lead Sponsor
U
University Hospital, Bordeaux
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cryptorchidism is the most common birth defect affecting male newborns, requiring surgery in childhood and increasing the risk of fertility problems and cancer. Its rising frequency in some countries suggests causes beyond genetics, including genetic, hormonal, and environmental factors. Animal studies indicate that exposure to endocrine disruptors may interfere with the normal migration of the testes before birth. This research aims to investigate whether environmental exposures, particularly to endocrine disruptors, are linked to cryptorchidism in boys. The study involves measuring the exposure of parents, especially job-related exposure during pregnancy, to endocrine disruptors. Parents of male children with and without cryptorchidism will be evaluated to assess possible differences in environmental exposure. This measurement focuses on the period during pregnancy when fetal testicular migration occurs, to understand the potential impact of these exposures. Participants will be parents of male children from newborn age up to 18 years old who have had surgery for cryptorchidism. Researchers will collect information about parental exposure to endocrine disruptors and track the frequency of such job exposures. The main outcome measured is the frequency of parental job exposure to endocrine disruptors within one day. The study excludes children with other endocrine diseases or genital/urinary abnormalities to focus on cryptorchidism specifically.
CONDITIONS
Official Title
Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Parents of male children from the neonatal period to 18 years of age (during surgery) with cryptorchidism
You will not qualify if you...
- Parents of children without endocrine disease (adrenal, hypothalamic-pituitary, phosphocalcic, thyroid, diabetes, etc.)
- Parents of children without an associated genital or urinary defect (hypospadias, micropenis, renal and bladder abnormalities)
- Testicular ectopia (testis outside of normal migration path)
- Anorchidism and evanescent testicles, united or bilateral
- Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)
- Cryptorchidism as part of a polymalformative syndrome, including neurological involvement
AI-Screening
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Trial Site Locations
Total: 1 location
1
University hospital of Montpellier
Montpellier, France, 34295
Actively Recruiting
Research Team
N
Nicolas KALFA, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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