Actively Recruiting
The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
Led by University of Leicester · Updated on 2026-04-30
130
Participants Needed
1
Research Sites
650 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this study the investigators are aiming to recruit 130 patients with heart failure with preserved ejection fraction who are obese and non-obese to undergo CT and MRI scans, as well as some other investigations including blood tests, to help investigate if having more fat around the heart leads to worse heart function in this condition. This may lead to the development of new treatments aimed at lowering fat levels around the heart and in the rest of the body, specifically to treat HFpEF.
CONDITIONS
Official Title
The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant is willing and able to give informed consent for participation in the study.
- Aged 6518 years old
- Diagnosed with HFpEF by an experienced cardiologist or signs and symptoms of heart failure with a HFA-PEFF score 6515
- Able to understand written English
You will not qualify if you...
- Left ventricular ejection fraction less than 45%
- History of recovered ejection fraction below 40%, unless due to tachycardia induced cardiomyopathy (e.g., atrial fibrillation or atrial flutter)
- Severe primary valvular heart disease
- HFpEF caused by infiltrative cardiomyopathy (cardiac amyloidosis or sarcoidosis), genetic hypertrophic cardiomyopathy, restrictive cardiomyopathy, pericardial disease, or congenital heart disease
- Known heritable, idiopathic, or drug-induced pulmonary arterial hypertension
- Absolute contraindications to cardiac CT or MRI, including estimated glomerular filtration rate (eGFR) 6430 ml/min/1.73m2; patients with MRI-compatible devices are excluded
- Women who are pregnant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Glenfield Hospital, University Hospitals of Leicester
Leicester, Leicestershire, United Kingdom, LE3 9QP
Actively Recruiting
Research Team
G
Gaurav S Gulsin, MBChB(Hons)
CONTACT
S
Sarah L Ayton, MBBS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here