Actively Recruiting
The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric
Led by Xijing Hospital · Updated on 2023-08-29
1000
Participants Needed
1
Research Sites
363 weeks
Total Duration
On this page
Sponsors
X
Xijing Hospital
Lead Sponsor
Y
Yuncheng Central Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
ECDNA is almost non-existent in normal cells, but exists in nearly half of human cancer cells, indicating that studying such abnormal DNA is of great significance for our understanding of tumor formation and evolution. The changes in ecDNA expression in intestinal type gastric cancer may be closely related to the occurrence and development of gastric cancer. Dynamic monitoring of changes in ecDNA expression in the gastric mucosa may help predict the occurrence of gastric cancer and guide subsequent treatment. By collaborating with multiple endoscopic centers to conduct gastroscopy biopsies on patients with gastric precancerous lesions, we aim to further explore the role of ecDNA in the occurrence and development of gastric cancer through continuous follow-up.
CONDITIONS
Official Title
The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years old
- Patients planning to undergo gastroscopy or surgical treatment for gastric adenocarcinoma
- Biopsy recommended by endoscopy doctors to confirm diagnosis
- Good physical and mental health without serious diseases or other systemic cancers
- Presence of at least one gastric condition such as non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, heterogeneous hyperplasia (low or high grade intraepithelial neoplasia), or gastric adenocarcinoma
- Signed informed consent form
You will not qualify if you...
- Pathology shows other stomach cancers like stromal tumors or lymphoma
- Patient or family does not consent to use of specimens for research
- Received neoadjuvant therapy or has other malignant tumors before gastroscopy or surgery
- Gastric cancer not completely removed (non R0 resection)
- Pregnant or breastfeeding women
- History of drug abuse including alcohol and tobacco
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xijing Hospital of Digestive Diseases
Xi'an, Shaanxi, China, 710000
Actively Recruiting
Research Team
W
wei jiangpeng, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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