Actively Recruiting
The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
Led by Icahn School of Medicine at Mount Sinai · Updated on 2025-07-04
10
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to understand the effects of HIV cure strategies on the virus and immune cells that reside within the gastrointestinal tract. Subjects receiving therapies with the potential for HIV cure will undergo a colonoscopy to obtain gastrointestinal tissue for research assays. This study will test whether receiving these therapies will induce changes in the immune cells in the gastrointestinal tract and reduce the tissue-associated HIV viral levels.
CONDITIONS
Official Title
The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Provision of signed and dated informed consent form
- Willingness to comply with all study procedures and availability for the study duration
- Male or female aged 18 to 75 years
- Chronic HIV-1 infection confirmed by approved tests
- Receiving treatment with a molecule with potential for HIV cure
- Willingness and ability to undergo colonoscopy twice during the study
You will not qualify if you...
- Known coagulopathy or altered coagulation studies
- Pregnancy or plans for pregnancy during the study
- Inflammatory Bowel Disease, diarrheal disease, or other gastrointestinal diseases affecting the intestinal mucosa
- Current sexually transmitted infection
- Any condition that may impair study compliance or completion as judged by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
Research Team
F
Francesca Cossarini, MD
CONTACT
S
Saurabh Mehandru, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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