Actively Recruiting
The Role of Granulation Tissue in Periodontal Regeneration
Led by Riga Stradins University · Updated on 2025-11-28
46
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
Sponsors
R
Riga Stradins University
Lead Sponsor
U
University of Turku
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in people with severe periodontitis (gum disease). Researchers aim to denote if these tissues may play role in healing after periodontal treatment. Researchers will also compare smokers and non-smokers to see if smoking disrupts the healing potential or infectious properties of granulation tissue. Participants will provide gingival fluid (before) and granulation tissue samples (at the time of) periodontal surgery. The main questions this study aims to answer are: 1. Do infra- and supra-osseous granulation tissues have different healing potential and infectious properties? 2. How do these tissues differ in people who smoke compared to people who do not smoke?
CONDITIONS
Official Title
The Role of Granulation Tissue in Periodontal Regeneration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Both genders
- Systemically healthy
- Smokers (smoking at least 10 cigarettes a day or electronic cigarettes daily or quit less than 5 years ago) and non-smokers (never smoked, smoke no more than once a month, or quit at least 5 years ago)
- Aged 18 years and over
- History of severe periodontitis (Stage III or IV, Grade B or C) with at least one vertical bone defect (≥3 mm infrabony component) in premolar-molar area after non-surgical treatment
- Plaque index and bleeding on probing of 20% or lower before surgery
You will not qualify if you...
- Systemic diseases affecting study results (uncontrolled type 2 diabetes with HbA1c >7%, recent myocardial infarction or stroke within 6 months, blood coagulation disorders)
- Use of medications affecting study results (anti-osteoporotic drugs, statins, corticosteroids, calcium channel blockers, cyclosporine A, antiepileptics, antipsychotics, antidepressants, chemotherapy or radiotherapy)
- Current pregnancy or breastfeeding
- Use of systemic antibiotics within 6 months before study
- Need for antibiotic premedication before periodontal treatment
- Prosthetic factors on teeth with bone defects preventing clinical measurements
- Lack of motivation for proper dental care or to complete periodontal treatment
- Strong vomiting reflex preventing adequate periodontal treatment
AI-Screening
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Trial Site Locations
Total: 1 location
1
Riga Stradins University Institute of Stomatology
Riga, Latvia, LV-1013
Actively Recruiting
Research Team
D
Dārta E Emuliņa, DDS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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