Evaluating Guided Tissue Regeneration Using PRF-Medium Plug and ACM Membrane for Healing and Quality of Life in Patients with Apico-Marginal Defects and Interproximal Bone Loss

What this Trial Is About

This research aims to evaluate the healing outcomes and quality of life in patients with apico-marginal defects and interproximal involvement related to endodontic and periapical diseases. The study compares the combined use of PRF-Medium plug and acellular chorionic membrane ACM with conventional endodontic surgery techniques. It focuses on patients with non-vital teeth suffering from chronic suppurative apical periodontitis and persistent defects, assessing whether this new combination improves recovery and patient wellbeing. Participants will undergo endodontic micro-surgery, where one group receives surgery with the placement of PRF-Medium plug and ACM membrane, while the comparison group undergoes surgery without these materials. The study involves two groups one treated with guided tissue regeneration GTR using the ACM membrane and PRF plug, and the other with surgery alone. The interventions are randomized, and the study employs triple masking to reduce bias. Throughout the 12 months following surgery, participants will be monitored with 2D periapical radiographs and 3D cone-beam computed tomography CBCT imaging to assess periapical healing. Quality of life assessments are also conducted from baseline to 12 months to evaluate patient outcomes. The study includes regular follow-ups to measure healing progress and patient-reported wellbeing, with the total participation duration being one year.

Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication